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NTR: venom-mediated vasoconstriction via bradykinin receptor antagonism and venom-mediated vasoconstriction via endothelin receptor agonism #30211

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FJungo opened this issue Apr 30, 2025 · 0 comments

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@FJungo
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FJungo commented Apr 30, 2025

Hello
here are 2 new terms to integrate to GO. A third term is suggested for increasing coherence.
Thanks
Florence

NEW - P: GO:xxx ; venom-mediated vasoconstriction via bradykinin receptor antagonism
child of P: GO:0044499 ; venom-mediated vasoconstriction
is_a : F: GO:0048019 - receptor antagonist activity
PMID:16277978
def. A process in which an organism promotes the narrowing (constriction) of blood vessels,
by inhibiting the widening (dilation) of blood vessels in another organism via the action of a venom,
concomittantly increasing blood pressure in the bitten/stung organism.

NEW- P: GO:xxx ; venom-mediated vasoconstriction via endothelin receptor agonism
NEW is_a : F: GO:xxx - receptor agonist activity (to create to be coherent with receptor antagonist activity)
child of P: GO:0044499 ; venom-mediated vasoconstriction
PMID:21889567
def. A process in which an organism initiates, promotes, or enhances the narrowing (constriction) of blood
vessels by stimulating endothelin receptors in another organism via the action of a venom, concomittantly increasing blood pressure in the bitten/stung organism.

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