Workflow 3B Module 1: Molecular & Cellular Physiology

[karafecho]

MCATS Questions Focused on Molecular & Cellular Physiology

1. Major histocompatibility complex (MHC) refers to a large group of genes that code for proteins that play an essential role in which of the following?
Correct: Antigen presentation to T lymphocytes
Incorrect: Phagocytosis by neutrophils; Antigen presentation to B lymphocytes; Phagocytosis by macrophages

Mini-hackathon notes:
● MHC -> gene family -> enrich biological process
● GO terms available for antigen presentation to T lymphocytes, etc.
● SemMed terms for MHC
● Uniprot KB terms for gene family for MHC
● GO terms for molecular function

Biolink node for gene family -> gene node -> process

2. Hormones travel through the blood stream and bind to receptors located on target cells. Which of the following would NOT bind to transmembrane proteins on the target cells?
Correct: Estrogen
Incorrect: Insulin; Antidiuretic Hormone; Prolactin

3. Which of the following is NOT true regarding ligand-gated ion channels?
Correct: Open or close in response to deformations in the cell membrane
Incorrect: Can have intracellular binding sites; React quickly to a stimulus or ligand; Can exhibit allosteric binding

Mini-hackathon notes:
● Which of the following is TRUE regarding ligand-gated ion channels?
● Uniprot?
● Tricky because answer types differ; could rework as four yes/no questions

4. In the scenario of adrenaline interaction with its G-protein coupled receptor, which of the following functions as a second messenger?
Correct: Cyclic AMP
Incorrect: The alpha subunit; Adenylate cyclase; GTP

5. Which of the following hormones would bind to receptors located on the inside of a cell?
Correct: Testosterone
Incorrect: Growth Hormone; Follicle-Stimulating Hormone; Prolactin

Comment
This ticket is for general considerations about Workflow 3B, Module 1 as a whole. Separate tickets may be created for issues specific to a particular submodule.

[karafecho]

Green/Gamma code for Question 1 can be found here.